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Updated: Jun 5, 2026
07:33
A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Enteral feed obstructing its own way
Vikas Kesarwani1, Dhaval R Ghelani, Graham Reece
1Department of Intensive Care Medicine, Blacktown Hospital, Blacktown Road, Blacktown NSW 2148, Australia.
Summary
Solidified enteral feeds can cause esophageal obstruction in intensive care unit (ICU) patients. Avoiding factors like reflux and low gastric pH may prevent this rare complication.
Area of Science:
- Critical care medicine
- Gastroenterology
- Nutritional support
Background:
- Enteral nutrition is crucial for critically ill patients.
- Esophageal obstruction from solidified formula is a rare but serious complication.
- Understanding causative factors is essential for prevention.
Observation:
- Casein-based enteral formulas can solidify in the esophagus.
- Gastroesophageal reflux may contribute to formula solidification.
- Low gastric pH and reduced digestive enzyme activity are implicated.
Findings:
- Solidification of enteral feeds in the esophagus is linked to specific patient conditions.
- Factors promoting solidification include reflux, highly acidic gastric environments, and decreased enzymatic digestion.
- These factors facilitate the hardening of casein-based formulas.
Implications:
- Recognizing and managing gastroesophageal reflux can prevent obstruction.
- Adjusting enteral feeding strategies in low pH or low enzyme environments may be necessary.
- Proactive identification of risk factors can improve patient safety and outcomes in ICUs.
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