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Related Concept Videos

Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

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Related Experiment Video

Updated: Jun 5, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Quantification of HBsAg: basic virology for clinical practice.

Jung Min Lee1, Sang Hoon Ahn

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, South Korea.

World Journal of Gastroenterology
|January 22, 2011
PubMed
Summary
This summary is machine-generated.

Quantifying Hepatitis B surface antigen (HBsAg) offers new insights into viral replication and clinical applications. Understanding HBsAg variants is crucial for diagnostics and immune escape mutant detection.

Keywords:
Hepatitis B surface antigenHepatitis B virusQuantitative assayVirology

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Last Updated: Jun 5, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis B surface antigen (HBsAg) is a key diagnostic marker for Hepatitis B virus (HBV) infection.
  • Current understanding of HBsAg production and secretion mechanisms remains incomplete.
  • Quantitative HBsAg assays enable monitoring of viral replication, expanding clinical utility.

Purpose of the Study:

  • To review current concepts and challenges in HBsAg quantification.
  • To explore the biologic nature and method principles of HBsAg assays.
  • To discuss clinically relevant topics, including HBsAg variants and their consequences.

Main Methods:

  • Review of existing literature on HBsAg quantification.
  • Analysis of principles behind quantitative HBsAg assays.
  • Examination of HBsAg variants, immune escape, and detection issues.

Main Results:

  • Quantitative HBsAg assays provide valuable data for viral replication monitoring.
  • HBsAg variants present challenges in detection and are linked to immune escape.
  • Understanding HBsAg's virologic aspects is essential for broader clinical application.

Conclusions:

  • Further research into HBsAg's biologic nature and variants is needed.
  • Maximal utilization of quantitative HBsAg assays can enhance clinical management of HBV infection.
  • A comprehensive understanding of HBsAg is vital for advancing HBV diagnostics and therapeutics.