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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Bone marrow-derived mesenchymal stem cells: current and future applications in the urinary bladder.

Beth A Drzewiecki1, John C Thomas, Stacy T Tanaka

  • 1Division of Pediatric Urology, Monroe Carell, Jr. Children's Hospital, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Stem Cells International
|January 22, 2011
PubMed
Summary

Bone marrow-derived mesenchymal stem cells offer potential for tissue regeneration. This review explores their application in urinary bladder tissue engineering and future genitourinary system uses.

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Urology

Background:

  • Mesenchymal stem cells (MSCs) are multipotent adult stem cells found in various tissues.
  • Bone marrow-derived MSCs (BM-MSCs) exhibit self-renewal and differentiation capabilities.
  • BM-MSCs possess low immunogenicity, making them attractive for therapeutic applications.

Purpose of the Study:

  • To review the current applications of BM-MSCs in urinary bladder tissue engineering.
  • To explore the potential future applications of BM-MSCs in the genitourinary system.
  • To highlight the underrepresentation of genitourinary system research concerning BM-MSCs.

Main Methods:

  • Literature review of studies on BM-MSCs and tissue regeneration.
  • Focus on research involving BM-MSCs in the context of the urinary bladder.
  • Analysis of current paradigms and future directions for BM-MSC applications.

Main Results:

  • BM-MSCs show promise for tissue regeneration and repair.
  • Existing research has extensively explored MSCs in multiple organ systems.
  • The genitourinary system, particularly the urinary bladder, is an underrepresented area for BM-MSC research.

Conclusions:

  • BM-MSCs are a viable option for urinary bladder tissue engineering.
  • Further research is needed to fully understand and utilize BM-MSCs in the genitourinary system.
  • Expanding BM-MSC applications could revolutionize regenerative medicine in urology.