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VURD Syndrome in a Female
A Zaccara1, M P Pascali, A Marciano
1Department of Urology, Bambino Gesu' Children's Hospital, 00165 Rome, Italy.
Advances in Urology
|January 22, 2011
Summary
Vesicoureteral reflux with a nonfunctioning kidney (VURD) syndrome and fetal ascites can occur in female infants with lower urinary tract obstruction. These conditions act as protective mechanisms against urinary tract pressure, requiring specialist consultation.
Area of Science:
- Pediatric Urology
- Fetal Medicine
- Neonatal Surgery
Background:
- Vesicoureteral reflux with a nonfunctioning kidney (VURD) syndrome is typically described in males as a pressure-relief mechanism in lower urinary tract obstruction.
- Associated findings like fetal ascites and urinomas have also been exclusively reported in males.
Purpose of the Study:
- To report a rare case of VURD syndrome and fetal ascites in a female infant with congenital urethral hypoplasia.
- To highlight that these perinatal protective mechanisms can occur in females with lower urinary tract obstruction.
Main Methods:
- Diagnostic workup of a premature female infant presenting with signs of outflow obstruction.
- Review of obstetrical history including early-onset ascites.
- Surgical intervention for congenital urethral hypoplasia.
Main Results:
- The patient exhibited congenital urethral hypoplasia and unilateral reflux into a dysplastic kidney (VURD syndrome).
- Early-onset ascites, requiring serial aspirations, was noted.
- Reconstructive surgery yielded positive outcomes.
Conclusions:
- Lower urinary tract obstruction in female infants can manifest with VURD syndrome and fetal ascites, mirroring protective mechanisms seen in males.
- These findings necessitate careful perinatal specialist counseling and management.
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