The representative porcine model for human cardiovascular disease

Area of Science:

• Biomedical research
• Translational science
• Preclinical studies

Background:

• Scientific discoveries require translation to improve human health.
• Preclinical testing using animal models is essential for technology development.
• Small animal models offer molecular insights but differ significantly from humans in cardiovascular characteristics.

Purpose of the Study:

• To highlight the necessity of large animal models in preclinical research.
• To provide an overview of commonly used large animal models.
• To emphasize the specific utility of porcine models in preclinical studies.

Main Methods:

• Review of existing literature on animal models for preclinical research.
• Comparative analysis of cardiovascular characteristics between small and large animal models and humans.
• Focus on the application of porcine models in translational studies.

Main Results:

• Small animal models have limitations in replicating human cardiovascular physiology.
• Large animal models exhibit greater physiological similarity to humans, aiding translation.
• Porcine models are frequently utilized and well-suited for various preclinical investigations.

Conclusions:

• Large animal models are indispensable for advancing discoveries from basic science to clinical therapies.
• Porcine models represent a valuable tool for preclinical testing, facilitating the development of human interventions.
• Effective preclinical strategies necessitate the judicious selection of appropriate animal models.