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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Related Experiment Video

Updated: Jun 5, 2026

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
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Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

Published on: January 7, 2014

Glioblastoma stem cells.

Ghazaleh Tabatabai1, Michael Weller

  • 1Laboratory of Molecular Neurooncology, Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland. ghazaleh.tabatabai@usz.ch

Cell and Tissue Research
|January 22, 2011
PubMed
Summary
This summary is machine-generated.

Glioblastoma stem cells, a small subpopulation of brain tumor cells, are key to understanding tumor growth and resistance. Further research into these cells may reveal new therapeutic targets for glioblastoma treatment.

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Last Updated: Jun 5, 2026

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Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion
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Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion

Published on: August 29, 2018

Area of Science:

  • Neuro-oncology
  • Cancer Stem Cell Biology
  • Molecular Oncology

Background:

  • Glioblastomas are aggressive primary brain tumors with poor prognoses.
  • Understanding tumor initiation and treatment resistance is crucial for improving outcomes.
  • Glioblastoma stem cells (GSCs) represent a critical cellular component in glioblastoma.

Purpose of the Study:

  • To summarize current knowledge on glioblastoma stem cells.
  • To discuss the implications of GSCs in glioblastoma biology.
  • To outline future research directions for GSCs in basic and clinical settings.

Main Methods:

  • Review of existing literature on glioblastoma stem cells.
  • Analysis of cellular and molecular mechanisms of glioblastoma initiation and resistance.
  • Synthesis of current findings and identification of research gaps.

Main Results:

  • Glioblastoma stem cells are recognized as a distinct subpopulation driving tumor growth.
  • These cells possess self-renewal and differentiation capabilities, contributing to tumor heterogeneity.
  • GSCs are implicated in resistance to conventional therapies like radiotherapy and chemotherapy.

Conclusions:

  • Glioblastoma stem cells are a significant focus for understanding and treating glioblastoma.
  • Targeting GSCs offers a promising strategy for novel therapeutic approaches.
  • Continued basic and clinical research is essential to translate GSC knowledge into effective treatments.