Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at the...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Light and Dark Cycles Control the Structural Evolution of Photoresponsive Supramolecular Systems.

Angewandte Chemie (International ed. in English)·2026
Same author

Ion-Pair Breakers and Anionic Brønsted Acids for Helmholtz-Layer Catalysis with External Electric Fields in Microfluidic Capacitors.

JACS Au·2026
Same author

Flipper dendrimers.

Chemical science·2026
Same author

3D self-assembly of cyclic peptides into multilayered nanosheets.

Chemical science·2026
Same author

2D Assemblies Based on a Tetraphenylethylene D,L-Cyclic Peptide Scaffold.

Angewandte Chemie (International ed. in English)·2025
Same author

Grafting Cell-Penetrating Poly(disulfide)s to Substrates of Interest: Dynamic Covalent Bioconjugation for Traceless Delivery.

Angewandte Chemie (International ed. in English)·2025

Related Experiment Video

Updated: Jun 5, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Anionic activators for differential sensing with cell-penetrating peptides.

Javier Montenegro1, Stefan Matile

  • 1Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.

Chemistry, an Asian Journal
|January 22, 2011
PubMed
Summary

Researchers developed synthetic sensing systems using peptides that react with odorants to create unique molecular fingerprints. These systems can identify individual analytes and complex mixtures, offering a new approach to chemical sensing.

More Related Videos

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide
07:33

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

Published on: December 19, 2020

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
10:26

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

Published on: December 20, 2017

Related Experiment Videos

Last Updated: Jun 5, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide
07:33

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

Published on: December 19, 2020

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
10:26

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

Published on: December 20, 2017

Area of Science:

  • Supramolecular Chemistry
  • Chemical Sensing
  • Synthetic Biology

Background:

  • Membrane-based sensing systems offer potential for detecting analytes.
  • Small molecules can be designed to interact with biological membranes.
  • Synthetic receptors are needed for selective analyte recognition.

Purpose of the Study:

  • To design and synthesize novel small peptides for membrane-based synthetic sensing.
  • To create amphiphilic anions from peptides and hydrophobic aldehydes/ketones.
  • To utilize these anions to activate polycations as anion transporters for analyte detection.

Main Methods:

  • Peptide design with negative charges and hydrazide groups.
  • Spontaneous reaction of peptides with hydrophobic aldehydes/ketones to form amphiphilic anions.
  • Utilizing fluorogenic vesicles with cell-penetrating peptides (CPPs) as polycationic transporters.
  • Analysis of analyte patterns using principal component and hierarchical cluster analysis.

Main Results:

  • Amphiphilic anions derived from peptides activated polycationic transporters in lipid bilayers.
  • Analyte detection was achieved by generating multidimensional patterns based on transporter activity.
  • Gemini-like peptide activators with two carboxylates and two tails showed optimal performance.
  • Excessive charges or tails reduced activity, unlike cationic activators for polyanionic transporters.

Conclusions:

  • Developed a novel membrane-based synthetic sensing system using peptide-derived amphiphiles.
  • Demonstrated the ability to generate unique molecular fingerprints for analyte identification, including mixtures.
  • Identified optimal structural features for anionic activators in this sensing system.