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Related Concept Videos

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.

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Related Experiment Video

Updated: Jun 5, 2026

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

[GABA receptors: structure and functions].

I N Tiurenkov, V N Perfilova

    Eksperimental'Naia I Klinicheskaia Farmakologiia
    |January 25, 2011
    PubMed
    Summary

    This review covers GABA receptors, crucial for central nervous system and peripheral functions. Understanding these cis-loop receptors and their modulators is key to neurological research.

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Pharmacology

    Context:

    • GABA receptors are integral membrane proteins involved in synaptic transmission.
    • They are implicated in various physiological and pathological processes within the central and peripheral nervous systems.

    Purpose:

    • To provide a comprehensive review of the structure, localization, physiology, and pharmacology of GABA receptors.
    • To elucidate the diverse allosteric modulators, agonists, and antagonists that interact with these receptors.

    Summary:

    • GABA receptors are cis-loop receptors composed of various subunits, found in both the central nervous system and peripheral organs.
    • Their activation modulates chloride ion permeability, leading to either depolarization (presynaptic inhibition) or hyperpolarization (postsynaptic inhibition).

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    Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

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  • These receptors feature distinct binding sites for GABA, benzodiazepines, barbiturates, ethanol, neurosteroids, and convulsants.

    • Impact:

    • This review consolidates current knowledge on GABA receptors, facilitating further research into their roles in health and disease.
    • Understanding GABA receptor pharmacology is crucial for developing novel therapeutic agents targeting neurological disorders.
    • Highlights the complexity of GABA receptor signaling and its modulation by various endogenous and exogenous compounds.