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Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

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Voltage sweep ion mobility spectrometry.

Eric J Davis¹, Michael D Williams, William F Siems

¹Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.

Analytical Chemistry

|January 25, 2011

Summary

This summary is machine-generated.

Ion mobility spectrometry (IMS) achieves better ion separation by using a novel voltage sweep algorithm. This method enhances resolving power and peak capacity across a wide range of ion sizes.

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Area of Science:

Analytical Chemistry
Physical Chemistry

Background:

Ion mobility spectrometry (IMS) separates ions in the gas phase.
IMS struggles to optimally separate both small and large ions simultaneously due to electric field dependency.
Low electric fields yield poor ion transmission and signal-to-noise ratios for IMS.

Purpose of the Study:

To develop a novel voltage algorithm for ion mobility spectrometry.
To enhance the separation power and peak capacity of IMS systems.
To maintain accurate drift time measurements across diverse ion mobilities.

Main Methods:

Implemented a voltage-sweep algorithm, scanning electric fields from low to high.
Monitored specific drift times during the voltage sweep.
Processed data to generate a 'voltage-sweep' spectrum.
Calculated optimal drift times for simultaneous scanning.

Main Results:

Achieved optimal separation for all ions across the entire mobility range.
Increased resolving power to the theoretical maximum for each peak.
Extended the peak capacity of the IMS system.
Maintained accurate drift time measurements.

Conclusions:

The novel voltage-sweep algorithm significantly improves IMS performance.
This method enhances separation power and peak capacity without compromising accuracy.
The software-based approach is adaptable to existing IMS instruments.