Related Experiment Video
Updated: Jun 5, 2026
Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine
Published on: October 27, 2023
Memantine effects on liver and adrenal gland of rats exposed to cold stress
Marcelo Ferreira1, Vitor E Valenti, Jose R Cisternas
1Laboratório de Escrita Científica, Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil. abreu.luizcarlos@gmail.com.
Background:
Memantine attenuates heart stress due cold stress, however, no study focused its effects on liver and adrenal gland. We evaluated its effects on lipid depletion in adrenal gland and glycogen depletion in liver of rats exposed to cold stress.
Methods:
Male rats divided into 4 groups: 1)Control (CON); 2)Memantine (MEM); 3)Induced cold stress (IH) and; 4)Induced cold stress memantine (IHF). Memantine were administrated by gavage (20 mg/kg/day) during eight days. Cold stress were performed during 4 hours once at - 8°C. Lipid and glycogen depletion were presented as its intensity levels.
Results:
Rats exposed to cold stress presented the highest glycogen (p < 0.001) and lipid depletion (p < 0.001) in liver and adrenal gland, respectively. We noted that memantine significantly reduced lipid depletion in adrenal gland and glycogen depletion in liver.
Conclusion:
Memantine prevented glycogen depletion in liver and lipid depletion in adrenal gland of rats under a cold stress condition.
