Related Experiment Video
Updated: Jun 5, 2026
07:12
Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
Published on: November 19, 2020
Transient haemodynamic events in neurologically compromised infants: a simultaneous EEG and diffuse optical imaging
R J Cooper1, Jeremy C Hebden, H O'Reilly
1Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, London, UK. rcooper@medphys.ucl.ac.uk
Neuroimage
|January 25, 2011
Summary
Newborn infants with neurological damage and seizures show unique haemodynamic events using simultaneous electroencephalography (EEG) and diffuse optical imaging (DOI). These findings highlight DOI
Area of Science:
- Neuroscience
- Medical Imaging
- Neonatal Research
Background:
- Neonatal seizures pose significant risks to brain development.
- Simultaneous electroencephalography (EEG) and diffuse optical imaging (DOI) offer potential for advanced neonatal brain monitoring.
- Understanding haemodynamic changes during neonatal neurological events is crucial.
Purpose of the Study:
- To investigate unique haemodynamic events in neurologically damaged neonates using combined EEG and DOI.
- To develop and validate a method for artifact rejection and event identification in DOI data.
- To compare haemodynamic patterns between neonates with neurological damage and healthy controls.
Main Methods:
- Conducted simultaneous EEG and DOI studies on newborn infants.
- Developed a novel artifact rejection and event identification algorithm for DOI data.
- Analyzed data from 4 neurologically damaged neonates (diagnosed with seizures) and 19 healthy controls.
Main Results:
- Consistently identified significant haemodynamic events in 3 out of 4 neurologically damaged infants.
- Observed events characterized by a slow increase in oxyhaemoglobin, followed by a rapid decrease.
- Found no comparable events in the control group, indicating specificity to neurological damage.
Conclusions:
- Simultaneous EEG and DOI can detect distinct haemodynamic signatures in neonates with neurological damage and seizures.
- The described artifact rejection and event identification method is effective for DOI data.
- This combined imaging approach shows promise for studying and monitoring neonatal brain injury.
