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Peptide p3 may play a neuroprotective role in the brain
Wenfei Han1, Tingting Ji, Bing Mei
1School of Stomatology, Tongji University, Shanghai 200072, China.
Medical Hypotheses
|January 25, 2011
Abstract:
Alzheimer's disease (AD) is an age-related neurodegenerative disease. The amyloid-β (Aβ) peptide is considered a major etiological factor in the development of AD. BACE1-deficient mice and forebrain-specific conditional presenilin1 and presenilin2 double knockout mice (presenilins cDKO mice) both lack Aβ, but exhibit completely different phenotypes. The peptide p3 may play a neuroprotective role. A lack of peptide p3 could trigger an inflammatory response in the brain of presenilins cDKO mice.
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