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Published on: July 1, 2018
Microarray analyses of THP-1 cells infected with Streptococcus suis serotype 2
Manli Liu1, Chen Tan, Liurong Fang
1Division of Animal Pathogens, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, PR China.
Veterinary Microbiology
|January 25, 2011
Summary
Streptococcus suis serotype 2 infection alters gene expression in human immune cells. Researchers identified 328 differentially expressed genes related to apoptosis, immunity, and cell signaling pathways.
Area of Science:
- Microbiology
- Immunology
- Molecular Biology
Background:
- Streptococcus suis serotype 2 (S. suis 2) is a significant zoonotic pathogen.
- Understanding S. suis 2 pathogenesis is crucial for disease control in pigs and humans.
Purpose of the Study:
- To investigate the molecular mechanisms of S. suis 2 pathogenesis.
- To identify host gene expression changes in human monocytic cells upon S. suis 2 exposure.
Main Methods:
- Oligonucleotide (oligo)-based microarray analysis was employed.
- Human monocytic THP-1 cells were exposed to S. suis 2 strain SC19.
- Differential gene expression profiling was performed.
Main Results:
- A total of 328 differentially expressed genes were identified.
- Key affected pathways include apoptosis, immunity, signal transduction, and chemokine production.
- The ubiquitin-proteasome system was also significantly impacted.
Conclusions:
- S. suis 2 significantly modulates host gene expression in human monocytic cells.
- These findings provide insights into the host-pathogen interactions during S. suis 2 infection.
- Further research can build upon these identified pathways for therapeutic targets.
