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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Allergic Reactions02:06

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Decrease in circulating Th17 cells correlates with increased levels of CCL17, IgE and eosinophils in atopic

Sayaka Hayashida1, Hiroshi Uchi, Yoichi Moroi

  • 1Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka, Japan. nusayaka@dermatol.med.kyushu-u.ac.jp

Journal of Dermatological Science
|January 25, 2011
PubMed
Summary
This summary is machine-generated.

Decreased T-helper 17 (Th17) cells correlate with atopic dermatitis (AD) severity. This study found lower Th17 cell counts in AD patients, suggesting their role in disease activity.

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Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • The clinical significance of CD4(+) T cell subsets (Th1, Th2, Th17, Treg) in atopic dermatitis (AD) is not fully understood.
  • Previous research has not simultaneously assessed these four T cell subsets in AD patients.

Purpose of the Study:

  • To investigate the correlation between circulating CD4(+) T cell subsets and AD severity parameters.
  • To evaluate Th1, Th2, Th17, and regulatory T (Treg) cell percentages in AD patients.

Main Methods:

  • Flow cytometry was used to analyze intracellular cytokine expression (IFN-γ, IL-4, IL-17) and Foxp3 in CD4(+) T cells.
  • Peripheral blood mononuclear cells from AD patients, chronic eczema patients, and normal controls were analyzed.
  • Serum CCL17, IgE levels, and eosinophil percentages were measured as AD severity markers.

Main Results:

  • AD patients showed significantly decreased Th1 and Th17 cells compared to controls.
  • Th2 and Treg cell percentages were similar between AD patients and controls.
  • A negative correlation was observed between Th17 cell frequency and AD severity markers (CCL17, IgE, eosinophils).

Conclusions:

  • Reduced circulating Th17 cells may be implicated in the pathogenesis and activity of atopic dermatitis.
  • Th17 cell levels could serve as a potential biomarker for AD severity.