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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

Bisphosphonates in orthopedic applications.

J Mark Wilkinson1, David G Little

  • 1Academic Unit of Bone Metabolism, Department of Human Metabolism, University of Sheffield, Metabolic Bone Centre, Sorby Wing, Northern General Hospital, Sheffield, UK. j.m.wilkinson@sheffield.ac.uk

Bone
|January 25, 2011
PubMed
Summary
This summary is machine-generated.

Bisphosphonates (BPs) show promise in treating osteonecrosis and enhancing bone repair and joint arthroplasty outcomes. Research indicates BPs may improve bone on-growth and fixation strength in orthopedic applications.

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Area of Science:

  • Orthopedics
  • Pharmacology
  • Skeletal Biology

Background:

  • Bisphosphonates (BPs) are potent skeletal agents with potential applications beyond metabolic disorders.
  • Understanding their role in orthopedic conditions like osteonecrosis, bone repair, and joint arthroplasty is crucial.

Purpose of the Study:

  • To review current research on bisphosphonate applications in managing osteonecrosis, bone repair, and joint arthroplasty.
  • To explore the potential of bisphosphonates as adjunctive therapies in orthopedic problems.

Main Methods:

  • Review of animal studies and limited human data on bisphosphonate use in osteonecrosis models.
  • Analysis of research on bisphosphonates in bone repair, considering dosing and administration effects.
  • Examination of animal and clinical studies on bisphosphonates in joint arthroplasty, including bone on-growth and fixation.

Main Results:

  • Animal studies suggest bisphosphonates decrease bone resorption in osteonecrosis models, with ongoing clinical trials.
  • Bisphosphonates' effect on bone healing is debated; longer dosing intervals appear more beneficial in animal studies.
  • Animal studies indicate bisphosphonates may enhance bone on-growth in joint arthroplasty; clinical studies show inhibition of periprosthetic bone loss, but not wear-particle-induced osteolysis.

Conclusions:

  • Bisphosphonates demonstrate potential benefits in osteonecrosis, bone repair, and joint arthroplasty, though further clinical validation is needed.
  • Optimizing bisphosphonate dosing and administration is key to maximizing benefits and minimizing adverse effects in bone healing.
  • Combined therapy with anabolic agents and bisphosphonates shows promise for bone repair by modulating both anabolic and catabolic pathways.