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Updated: Jun 5, 2026
Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
Published on: March 15, 2019
Immunoglobulin light (IgL) chains in ectothermic vertebrates
Eva-Stina Edholm1, Melanie Wilson, Eva Bengten
1Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Abstract:
Four major ancesteral IgL isotypes have been identified κ, λ, σ and σ-cart. However, depending on the vertebrate class the genomic representation of these isotypes differs in regards to what is encoded in the germline and how these genes are organized. Also, the relative contribution of each isotype in immune responses varies. This review focuses on the IgL chains of ectothermic vertebrates, specifically the number of different isotypes, their phylogenetic relationship, genomic organizations and expression.
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