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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

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Receptor Downregulation in MVBs01:15

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Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Hedgehog morphogen: from secretion to reception.

Armel Gallet1

  • 1Institut de Biologie du Développement & Cancer - IBDC, Université de Nice Sophia-Antipolis, UMR6543 CNRS, Centre de Biochimie, Parc Valrose, 06108 Nice cedex 2, France. gallet@unice.fr

Trends in Cell Biology
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PubMed
Summary

The Hedgehog morphogen is crucial for animal development and cancer. This review details accessory molecules controlling Hedgehog signaling spread and activity, essential for cellular coordination.

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Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Molecular Biology

Background:

  • Cell-to-cell communication is vital for development, often mediated by signaling molecules like morphogens.
  • The Hedgehog morphogen plays a critical role in animal development, growth control, and tissue patterning.
  • Dysregulated Hedgehog signaling is implicated in various cancers, highlighting its importance in disease.

Purpose of the Study:

  • To review the accessory molecules involved in the secretion, release, spread, and reception of the Hedgehog morphogen.
  • To elucidate the mechanisms controlling Hedgehog signaling spread and activity during development and disease.

Main Methods:

  • Literature review focusing on recent data regarding Hedgehog morphogen regulation.
  • Analysis of accessory factors influencing Hedgehog processing, release, and reception.
  • Synthesis of current understanding of Hedgehog spread dynamics.

Main Results:

  • Hedgehog spread and activity are actively regulated by specific accessory molecules, not passive diffusion.
  • These accessory molecules are critical for processing, release, intercellular spread, and reception of Hedgehog.
  • Recent findings provide new insights into the complex regulatory network governing Hedgehog signaling.

Conclusions:

  • Understanding the factors controlling Hedgehog spread is key to comprehending its developmental roles.
  • Targeting Hedgehog pathway regulators offers potential therapeutic strategies for developmental disorders and cancer.
  • Further research into these accessory molecules will advance our understanding of morphogen biology.