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Serum transforming growth factor beta-1 post hip fracture repair in elderly patients
Yichayaou Beloosesky1, Avraham Weiss, Avital Hershkovitz
1Department of Geriatrics, Rabin Medical Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel. beloy@clalit.org.il
Background:
To determine the kinetics of serum transforming growth factor beta-1 (TGF-β1) in aged hip fracture patients during a month post-op. and determine its relationship to complications and cognitive status.
Methods:
Forty-one elderly patients were prospectively followed. Serum TGF-β1 was obtained during the first 10h post-fracture (baseline) and pre-surgery, 48-60 h post-op., 7 and 30 days post-op.
Results:
Mean age was 81.8±7.7, range 68-97 years. A significant increase in serum TGF-β1 (from baseline) was observed on the seventh day post-op., lasting for at least 1 month (p = 0.004). Sixteen patients experienced post-op. complications. Serum TGF-β1 of patients with complications was significantly higher compared to patients without complications (p = 0.039). More complications were found in impaired mental status (IMS) patients (9/12) compared to cognitively normal patients (10/29), (p = 0.037). However, no differences were found in serum TGF-β1 between IMS and normal patients, nor was a correlation found between age and TGF-β1 production. No differences were found between genders.
Conclusions:
There is a distinct increase in serum TGF-β1, a week post hip fracture repair, lasting for at least a month, which is significantly higher in patients with post-op. complications. TGF-β1 seems to be essential to the healing process post hip fracture repair; still its clinical applications have as yet to be determined.
