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Related Experiment Video

Updated: Jun 5, 2026

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale

¹⁵N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale

Published on: April 19, 2021

A fully integrated IQ-receiver for NMR microscopy.

Jens Anders¹, Paul SanGiorgio, Giovanni Boero

¹Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 17, CH-1015 Lausanne, Switzerland. jens.anders@epfl.ch

Journal of Magnetic Resonance (San Diego, Calif. : 1997)

|January 25, 2011

Summary

We developed a compact CMOS receiver for micro-magnetic resonance imaging, achieving 8 μm resolution. This integrated system enhances micro-MRI capabilities for detailed imaging applications.

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15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale

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Published on: April 19, 2021

Simultaneous Data Collection of fMRI and fNIRS Measurements Using a Whole-Head Optode Array and Short-Distance Channels

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Published on: October 20, 2023

Area of Science:

Electrical Engineering
Biomedical Engineering
Physics

Background:

Micro-magnetic resonance imaging (micro-MRI) requires highly sensitive and integrated receiver systems.
Existing systems often face limitations in resolution and component integration.

Purpose of the Study:

To present a fully integrated CMOS receiver for micro-MRI.
To develop a custom micro-gradient system for enhanced imaging.
To demonstrate high-resolution imaging capabilities.

Main Methods:

Designed and fabricated a CMOS receiver chip (0.13 μm technology) with an on-chip detection coil, low-noise amplifier, and mixer.
Integrated the receiver with a custom-made micro-gradient system.
Achieved a time-domain spin sensitivity of 5×10^14 spins/Hz.

Main Results:

The integrated CMOS receiver operates at 300 MHz and occupies a small chip area (950 × 800 μm²).
The system achieved an 8 μm isotropic resolution in phantom imaging.
Demonstrated high spin sensitivity crucial for micro-MRI.

Conclusions:

The presented integrated CMOS receiver and micro-gradient system enable high-resolution micro-MRI.
This technology advances the development of compact and sensitive micro-MRI devices.
The achieved resolution opens possibilities for detailed biological and material science imaging.