Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immunoprecipitation

Immunoprecipitation

Immunoprecipitation, or IP, is a widely used technique that employs protein-antibody interactions to isolate proteins or protein complexes in their native state for studying protein-protein interactions, quaternary structures, or supramolecular complexes. Various modifications of the technique, including chromatin IP, cross-linking IP, and fluorescence IP, are commonly used.
Chromatin Immunoprecipitation
Chromatin immunoprecipitation, also known as ChIP, is used to study protein-DNA or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A serologic weak D expressed by a combined weak D type 1/41.0.1 allele.

Transfusion·2026

Same author

International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems.

Vox sanguinis·2025

Same author

Kell and Kx blood group systems: an update.

Immunohematology·2025

Same author

JK*01(307C) encodes a JK null allele.

Transfusion·2025

Same author

Cell-Free DNA Analysis for the Determination of Fetal Red Blood Cell Antigen Genotype in Individuals With Alloimmunized Pregnancies.

Obstetrics and gynecology·2024

Same author

Defining the breakpoints of hybrid blood group alleles.

Blood transfusion = Trasfusione del sangue·2024

Same journal

Successful hematopoietic progenitor cell collections using fenestrated peripheral catheters: Safety, performance, and engraftment outcomes in a case series.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026

Same journal

Therapeutic apheresis in transition: New indications and the emergence of precision apheresis.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026

Same journal

Therapeutic plasma exchange and immunomodulatory strategies in post-infectious syndromes: A review of immune dysregulation in PTLDS, long COVID, ME/CFS, and PANS/PANDAS.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026

Same journal

Therapeutic plasma exchange in Alzheimer's disease: From clinical trial to real-world evidence.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026

Same journal

Successful treatment of pure red cell aplasia with Orelabrutinib following major ABO-incompatible hematopoietic stem cell transplantation for acute myeloid leukemia: A case report.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026

Same journal

Technological advances in selective plasma adsorption: The MTx.100 column and the emergence of subtractive precision medicine.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Published on: June 29, 2020

DNA-based methods in the immunohematology reference laboratory.

Marion E Reid¹, Gregory A Denomme

¹Laboratory of Immunochemistry, New York Blood Center, 310 East 67th Street, New York, NY 10065, United States. mreid@nybloodcenter.org

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis

|January 25, 2011

Summary

This summary is machine-generated.

Molecular methods enhance immunohematology reference laboratory capabilities beyond traditional hemagglutination. DNA-based testing accurately predicts blood groups, resolves discrepancies, and identifies antigen-negative units for transfusion support.

More Related Videos

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

Related Experiment Videos

Last Updated: Jun 5, 2026

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Published on: June 29, 2020

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

Area of Science:

Immunohematology
Molecular Biology
Genetics

Background:

Traditional hemagglutination methods are standard in immunohematology reference laboratories but have limitations in resolving complex cases.
Understanding the genetic basis of blood groups is crucial for advanced immunohematology diagnostics.

Purpose of the Study:

To explore the application of molecular approaches in immunohematology reference laboratories.
To highlight the benefits of DNA-based methods for resolving blood group complexities and improving transfusion services.

Main Methods:

Review of molecular techniques relevant to immunohematology.
Discussion of gene knowledge, DNA-based methodologies, and the molecular underpinnings of blood group systems.

Main Results:

DNA-based methods can accurately predict blood groups.
These methods effectively resolve ABO/Rh discrepancies and identify variant alleles.
Molecular testing facilitates screening for antigen-negative units, crucial for transfusion compatibility.

Conclusions:

Molecular approaches significantly expand the capabilities of immunohematology reference laboratories.
DNA-based testing is a valuable tool for managing blood group incompatibilities and ensuring patient transfusion safety.