Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Loop diuretics reduce lithium reabsorption without affecting bicarbonate and phosphate reabsorption.

E S Stokke1, J Ostensen, A Hartmann

  • 1Institute for Medical Experimental Research, University of Oslo, Ullevål Hospital, Norway.

Acta Physiologica Scandinavica
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural changes in renal arterioles in Type I diabetic patients.

Diabetologia·2002
Same author

Hepatocellular carcinoma in southern Germany: epidemiological and clinicopathological characteristics and risk factors.

Digestive diseases (Basel, Switzerland)·2002
Same author

Kidney function and glomerulopathy over 8 years in young patients with Type I (insulin-dependent) diabetes mellitus and microalbuminuria.

Diabetologia·2002
Same author

Massive steatosis hepatis: an unusual manifestation of Whipple's disease.

The American journal of gastroenterology·2002
Same author

Naftidrofuryl in the treatment of vascular dementia.

European archives of psychiatry and clinical neuroscience·2002
Same author

Influence of nonylphenol on the microbial community of lake sediments in microcosms.

The Science of the total environment·2002

Loop diuretics like ethacrynic acid and bumetanide significantly reduce lithium reabsorption in dogs. These diuretics may inhibit passive lithium transport in the kidney

Area of Science:

  • Nephrology
  • Pharmacology

Background:

  • Lithium is a mood stabilizer with a narrow therapeutic index.
  • Understanding its renal handling is crucial for managing lithium toxicity.
  • Loop diuretics are potent diuretics affecting renal ion transport.

Purpose of the Study:

  • To compare the effects of ethacrynic acid and bumetanide on lithium, bicarbonate, and phosphate reabsorption.
  • To investigate the mechanism of lithium reabsorption inhibition by loop diuretics.

Main Methods:

  • 16 anesthetized, normovolemic dogs were used.
  • Ethacrynic acid and bumetanide were administered at specific doses.
  • Renal reabsorption of lithium, bicarbonate, and phosphate was measured.

Main Results:

Related Experiment Videos

  • Both ethacrynic acid and bumetanide significantly reduced absolute and fractional lithium reabsorption.
  • Fractional chloride reabsorption was also significantly decreased by both diuretics.
  • Bicarbonate and phosphate reabsorption remained largely unaffected.

Conclusions:

  • Loop diuretics potently inhibit renal lithium reabsorption.
  • This inhibition is likely due to a reduction in the lumen-positive electrical potential in the thick ascending limb of Henle's loop, affecting passive cation transport.