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CC chemokine receptor 5 polymorphism in chronic periaortitis

Luigi Boiardi1, Augusto Vaglio, Davide Nicoli

  • 1Unità Operativa di Reumatologia, Hospital S. Maria Nuova, Reggio Emilia, Italy.

Rheumatology (Oxford, England)
|January 25, 2011
PubMed
Abstract

Insights

The CCR5Δ32 polymorphism may increase the risk of developing inflammatory abdominal aortic aneurysms (IAAA), a form of chronic periaortitis (CP). This genetic factor appears particularly relevant in IAAA patients without other atherosclerotic conditions.

Area of Science:

  • Genetics and Immunology
  • Vascular Biology
  • Rare Diseases

Background:

  • Chronic periaortitis (CP) is a rare fibro-inflammatory condition affecting the abdominal aorta, encompassing idiopathic retroperitoneal fibrosis (IRF) and inflammatory abdominal aortic aneurysm (IAAA).
  • The role of genetic factors, specifically chemokine receptor polymorphisms, in CP pathogenesis remains under investigation.

Purpose of the Study:

  • To investigate the association between the CC chemokine receptor 5 (CCR5)Δ32 polymorphism and susceptibility to chronic periaortitis (CP).
  • To determine if this polymorphism differentially affects the risk of developing IRF versus IAAA.
  • To explore the influence of established atherosclerotic disease on this association.

Main Methods:

  • Genotyping of the CCR5Δ32 polymorphism in 100 CP patients and 180 healthy controls.
  • Subgrouping CP patients into IRF and IAAA categories.
  • Analysis of patients with and without established atherosclerotic diseases (ischaemic heart disease, cerebrovascular disease, peripheral arterial disease).

Main Results:

  • The CCR5Δ32 genotype distribution differed between CP patients and controls (P=0.01).
  • The CCR5Δ32 allele was more frequent in CP patients (OR 2.8) and significantly more so in IAAA patients (OR 10.0, P=0.0001) compared to controls.
  • The CCR5Δ32 allele was notably more prevalent in IAAA patients without atherosclerotic disease (OR 34.0, P=0.00001) and more frequent in IAAA than IRF patients (OR 6.4, P=0.001).

Conclusions:

  • The CCR5Δ32 polymorphism is associated with an increased risk of developing the aneurysmal form of CP (IAAA).
  • This genetic association is particularly pronounced in IAAA patients without other established atherosclerotic conditions.
  • These findings suggest a potential role for chemokines in the pathophysiology of CP, especially IAAA.

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