Recurrent brain abscess induced by pulmonary arteriovenous fistula

Takanobu Kaido1, Yoshio Moriyama, Katsuhiro Ueda

  • 1Department of Neurosurgery, Oyodo Town General Hospital, Oyodo, Nara, Japan. kaido@ncnp.go.jp

Insights

Recurrent brain abscesses can stem from pulmonary arteriovenous fistulas (PAVF). Prompt diagnosis and treatment of PAVF are crucial for resolving brain abscesses and preventing recurrence.

Area of Science:

  • Neurology
  • Cardiology
  • Infectious Diseases

Background:

  • Brain abscesses associated with arteriovenous fistulas (AVF) present diagnostic challenges and a high recurrence rate.
  • Pulmonary arteriovenous fistulas (PAVF) can be an uncommon yet significant source of recurrent brain abscesses.

Observation:

  • A 69-year-old female presented with a recurrent brain abscess, initially misdiagnosed.
  • Initial symptoms included a left cerebral peduncle mass and decerebrate rigidity, improving with antibiotics.
  • A subsequent episode of left hemiparesis led to the discovery of a right frontal lobe cystic mass.

Findings:

  • Surgical exploration confirmed a brain abscess.
  • Coil embolization successfully treated an underlying pulmonary arteriovenous fistula (PAVF).
  • The patient experienced significant improvement in hemiparesis post-embolization.

Implications:

  • This case highlights the importance of investigating for PAVF in recurrent brain abscesses.
  • Early detection and management of PAVF are essential for successful treatment and cure of associated brain abscesses.
  • Comprehensive etiological investigation is critical for managing complex neurological infections.

Related Concept Videos

Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Pneumothorax-II01:27

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...