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Chorionic villus sampling and the risk of preeclampsia: a systematic review and meta-analysis
Ahmet Basaran1, Mustafa Basaran, Betül Topatan
1Department of Obstetrics and Gynecology, ACIBADEM Kayseri Hospital, Kayseri, Turkey. dr_ahmetbasaran@yahoo.com
Objective:
To perform systematic review and meta-analysis to evaluate the risk of preeclampsia after chorionic villus sampling (CVS).
Data Sources:
A systematic search of PubMED and Web of Science from inception through August 2010, and bibliographies of review articles and eligible studies were performed.
Methods Of Study Selection:
Six studies reported the risk of preeclampsia after CVS. All of the identified studies were retrospective and included in analysis.
Tabulation, Integration, And Results:
Reporting quality of the identified studies according to quality assessment scale for methodology in retrospective clinical reporting was moderate. Pooling was performed in two strata for control: (1) patients without any invasive prenatal diagnostic procedure served as control group: no significant difference was found in the odds ratio (OR) of preeclampsia (OR 0.79, 95% CI 0.38-1.64), severe preeclampsia (OR 0.49, 95% CI 0.04-5.78), gestational hypertension (OR 0.76, 95% CI 0.46-1.26), all pregnancy-induced hypertensive disorders (OR 0.80, 95% CI 0.46-1.41) between CVS and control groups. (2) Patients with amniocentesis combined with patients without any invasive prenatal diagnostic procedure served as control group: no significant difference was found in the OR of preeclampsia (OR 0.76, 95% CI 0.37-1.53), severe preeclampsia (OR 0.83, 95% CI 0.14-4.85), all pregnancy-induced hypertensive disorders (OR 0.92, 95% CI 0.55-1.53) between CVS and combined control groups.
Conclusion:
None of the included studies were randomized prospective trials designed to investigate the effect of CVS on preeclampsia. Accordingly, this review is limited by the heterogeneity, small number and retrospective nature of the available studies. CVS does not seem to increase the risk of preeclampsia or other pregnancy-induced hypertensive disorders. However, randomized prospective trials that are designed to investigate the risk of preeclampsia after CVS are needed to make a definite conclusion.
