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Multivariate optimization of formulation variables influencing flurbiprofen proniosomes characteristics
Ahmed S Zidan1, Mahmoud Mokhtar
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. Azidoon@yahoo.com
Journal of Pharmaceutical Sciences
|January 25, 2011
Summary
This study optimized flurbiprofen proniosomal transdermal gel formulations. Statistical design identified optimal surfactant and cholesterol levels for enhanced drug delivery and high entrapment efficiency.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Proniosomal gels offer advanced transdermal drug delivery.
- Flurbiprofen is a non-steroidal anti-inflammatory drug suitable for topical application.
Purpose of the Study:
- To optimize flurbiprofen proniosomal transdermal gel formulations.
- To investigate the impact of surfactant and cholesterol on drug permeation and entrapment.
Main Methods:
- A randomized full factorial design was employed.
- Nonionic surfactants and cholesterol were used in proniosome formulation.
- Drug permeation, steady-state transdermal flux (SSTF), and permeability coefficient (PC) were measured.
Main Results:
- Optimal formulation achieved 39.45% drug entrapment.
- High entrapment and permeation were correlated with surfactant side chain length and cholesterol content.
- Optimized formulation demonstrated significant transdermal flux and permeability through rabbit skin.
Conclusions:
- Statistical experimental design effectively optimized proniosomal gel formulations.
- Proniosomal gels show potential for efficient flurbiprofen transdermal delivery.
- Formulation variables critically influence proniosome performance and drug release kinetics.
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