Sequential release of antigens from chloroform-treated Staphylococcus epidermidis: application towards a possible vaccine
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1Department of Medical Microbiology, Medical School, University of Birmingham, Edgbaston, UK.
The Journal of Applied Bacteriology
|November 1, 1990
Abstract:
This study describes the properties of two potential Staphylococcus epidermidis vaccines prepared by chloroform treatment of bacteria and release of antigen from these chloroform-treated organisms. Both vaccines were antigenic on testing with homologous hyperimmune serum and induced immune reactivity in immunized rabbits. There was protective efficacy in mice against intraperitoneal challenge by Staph. epidermidis.