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Updated: Jun 5, 2026

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
09:45

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Published on: March 31, 2015

Zebrafish models for cancer.

Shu Liu1, Steven D Leach

  • 1Department of Surgery, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. shu.liu@jhmi.edu

Annual Review of Pathology
|January 26, 2011
PubMed
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This summary is machine-generated.

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Zebrafish are a valuable vertebrate model for studying cancer, offering key advantages for research. These advanced zebrafish cancer models provide new insights into cancer mechanisms and aid in drug discovery.

Area of Science:

  • Comparative oncology
  • Developmental biology
  • Genetics

Background:

  • Zebrafish (Danio rerio) are established vertebrate models for developmental studies.
  • Recent technical advancements have enabled the creation of sophisticated zebrafish cancer models.
  • These models mimic human cancers histologically and genetically.

Purpose of the Study:

  • To highlight the utility of zebrafish as a model system for human cancer research.
  • To emphasize the role of technical advances in developing relevant zebrafish cancer models.
  • To discuss the potential of zebrafish models in advancing cancer biology and drug discovery.

Main Methods:

  • Utilizing zebrafish as a model organism for cancer research.
  • Employing advanced techniques for generating genetically relevant cancer models.

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Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis

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Last Updated: Jun 5, 2026

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Published on: March 31, 2015

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  • Leveraging in vivo imaging, forward genetics, and transgenesis.

    • Main Results:

    • Zebrafish cancer models develop tumors resembling human malignancies.
    • These models exhibit striking histological and genetic similarities to human cancers.
    • The focus has shifted from validating zebrafish to utilizing its potential in cancer biology.

    Conclusions:

    • Zebrafish are a powerful and validated model for studying cancer biology.
    • The advantages of zebrafish, including imaging and genetic tools, facilitate cancer research.
    • Further exploration of zebrafish cancer models will yield unique insights and aid drug discovery.