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Resveratrol: a cardioprotective substance
1Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, 10595, USA. Joseph_Wu@nymc.edu
Annals of the New York Academy of Sciences
|January 26, 2011
Summary
Red wine consumption, particularly its polyphenol resveratrol, may offer cardioprotection. Studies show resveratrol has multifaceted heart-protective activities, potentially via specific protein interactions.
Area of Science:
- Cardiovascular research
- Nutritional science
- Molecular biology
Background:
- Coronary heart disease (CHD) remains a significant public health concern in the US.
- The "French paradox" observes low CHD incidence despite high risk factors, potentially linked to red wine consumption.
- Red wine's cardioprotective effects are hypothesized to stem from grape-derived polyphenols like resveratrol.
Purpose of the Study:
- To review in vitro and animal studies on resveratrol's cardioprotective effects.
- To identify specific proteins targeted by resveratrol, such as NQO2.
- To propose a mechanism and research roadmap for understanding resveratrol's benefits.
Main Methods:
- Review of in vitro studies on resveratrol.
- Analysis of animal studies investigating red wine and resveratrol.
- Examination of molecular targets of resveratrol, including NQO2.
Main Results:
- Resveratrol demonstrates diverse cardioprotective activities in experimental models.
- Evidence suggests resveratrol interacts with specific cellular proteins, including N-ribosyldihydronicotinamide:quinone oxidoreductase (NQO2).
- Both nongenomic and genomic mechanisms are implicated in resveratrol's action.
Conclusions:
- Resveratrol possesses significant potential for cardioprotection.
- Understanding resveratrol's molecular targets and mechanisms is crucial for further research.
- Further investigation is warranted to elucidate the full scope of resveratrol's cardiovascular benefits.
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