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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Videos

Skin ageing.

E Kohl1, J Steinbauer, M Landthaler

  • 1Department of Dermatology, Regensburg University Hospital, Regensburg, Germany. elisabeth.kohl@klinik.uni-regensburg.de

Journal of the European Academy of Dermatology and Venereology : JEADV
|January 26, 2011
PubMed
Summary
This summary is machine-generated.

Skin ageing occurs intrinsically and extrinsically, primarily due to ultraviolet radiation. Both processes involve reactive oxygen species and matrix metalloproteinases, leading to collagen degradation and impacting therapeutic strategies.

Related Experiment Videos

Area of Science:

  • Dermatology and aging research.
  • Molecular biology of skin aging.

Background:

  • Skin aging is a natural intrinsic process.
  • Extrinsic factors, especially ultraviolet (UV) radiation, accelerate skin aging (photoaging).
  • Photoaging is the primary cause of age-related skin changes in sun-exposed areas.

Purpose of the Study:

  • To explore the molecular similarities between intrinsic and extrinsic skin aging.
  • To highlight the role of reactive oxygen species and matrix metalloproteinases in skin aging.
  • To discuss the implications for therapeutic and preventive strategies.

Main Methods:

  • Comparative analysis of intrinsic and extrinsic skin aging mechanisms.
  • Focus on molecular pathways including oxidative stress and extracellular matrix degradation.
  • Review of existing literature on therapeutic interventions.

Main Results:

  • Intrinsic and extrinsic skin aging share common molecular pathways despite differing causes.
  • Reactive oxygen species formation and matrix metalloproteinase induction are key molecular events.
  • Fragmented collagen accumulation inhibits new collagen formation, creating a detrimental feedback loop.

Conclusions:

  • Understanding shared molecular mechanisms is crucial for effective skin aging management.
  • Therapeutic and preventive strategies are being developed based on these mechanisms.
  • Targeting key molecular players like reactive oxygen species and matrix metalloproteinases shows promise.