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Aortic stenosis in a patient with Hurler's syndrome after bone marrow transplantation
Naruhito Watanabe1, Petros V Anagnostopoulos, Anthony Azakie
1Department of Surgery, Division of Pediatric Cardiac Surgery, UCSF Benioff Children's Hospital, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Abstract:
We describe a case of severe aortic stenosis in a 16-year-old male with Hurler's syndrome who had prior bone marrow transplantation. The excised aortic valve leaflets showed characteristic pathologic findings of Hurler's syndrome. This is the first case report of aortic valve replacement in a patient with Hurler's syndrome treated with bone marrow transplantation that demonstrates progression of the aortic valve disease despite treatment.
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