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Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

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Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
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Spike-timing dependent plasticity in striatal interneurons.

Elodie Fino1, Laurent Venance

  • 1Dynamics and Pathophysiology of Neuronal Networks (INSERM UMR-S667), Center for Interdisciplinary Research in Biology, Collège de France, Paris, France. elodie.fino@college-de-france.fr

Neuropharmacology
|January 26, 2011
PubMed
Summary

This review explores synaptic plasticity in striatal interneurons, focusing on spike-timing dependent plasticity (STDP). Understanding these changes is key to basal ganglia function in learning and motor control.

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Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Basal Ganglia Function

Background:

  • The basal ganglia, crucial for motor planning and learning, rely on the striatum for processing information.
  • Striatal interneurons significantly influence striatal output neuron activity and information processing.
  • Interneurons receive direct cortical input and adapt to neural activation levels.

Purpose of the Study:

  • To review long-term synaptic efficacy changes in striatal interneurons.
  • To highlight spike-timing dependent plasticity (STDP) as a key Hebbian learning rule.
  • To examine the functional impact of interneuron plasticity on striatal output.

Main Methods:

  • Review of existing literature on corticostriatal plasticity.
  • Focus on spike-timing dependent plasticity (STDP) mechanisms.
  • Analysis of interneuron interactions with striatal output neurons.

Main Results:

  • Corticostriatal long-term synaptic plasticity, particularly STDP, occurs in striatal interneurons.
  • Interneuron plasticity modulates striatal output neuron excitability.
  • Local striatal network interactions amplify the effects of interneuron plasticity.

Conclusions:

  • Interneuron plasticity is a critical mechanism for adaptive learning in the basal ganglia.
  • STDP in interneurons shapes cortico-striatal information flow.
  • Understanding interneuron plasticity is essential for comprehending basal ganglia disorders.