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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Postmenopausal hormone therapy and venous thromboembolism.
Valérie Olié1, Marianne Canonico, Pierre-Yves Scarabin
1Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Hormones and Cardiovascular disease, F-94807 Villejuif, France.
Thrombosis Research
|January 26, 2011
Summary
Hormone therapy (HT) safety is improved by considering estrogen route, progestin type, and dose to minimize venous thromboembolism (VTE) risk in postmenopausal women.
Area of Science:
- Reproductive Endocrinology
- Thrombosis Research
- Pharmacology
Background:
- Hormone therapy (HT) effectively manages menopausal symptoms.
- Venous thromboembolism (VTE) is a significant risk associated with HT, particularly in younger postmenopausal women.
- Mitigating VTE risk is crucial for optimizing HT's benefit/risk profile.
Purpose of the Study:
- To review current findings on VTE risk in postmenopausal women using HT.
- To identify key factors influencing VTE risk in HT users.
Main Methods:
- Literature review of recent studies on VTE risk and HT.
- Analysis of epidemiological data and meta-analyses.
Main Results:
- Transdermal estrogen administration is confirmed as safe regarding VTE risk.
- Concomitant use of certain progestins, compared to progesterone, may elevate VTE risk.
- Higher doses of oral estrogens are associated with increased VTE risk.
Conclusions:
- Estrogen administration route is a critical factor in thrombotic risk.
- The type of progestogen used alongside estrogen influences VTE risk.
- Estrogen dosage is a significant determinant of VTE risk in postmenopausal HT users.
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