Factors influencing prognosis in patients with marfan syndrome after aortic surgery

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Published on: June 20, 2025

Linggen Gao1, Xianliang Zhou, Lin Zhang

  • 1Department of Cardiology, FuWai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal of Cardiothoracic and Vascular Anesthesia
|January 26, 2011
PubMed
Abstract

Insights

For Marfan syndrome (MFS) patients undergoing aortic surgery, high blood pressure predicts death, while body mass index and smoking predict reoperation. Managing these factors may improve long-term outcomes for MFS patients.

Area of Science:

  • Cardiovascular Surgery
  • Genetics
  • Thoracic Surgery

Background:

  • Marfan syndrome (MFS) can lead to fatal aortic aneurysm, rupture, or dissection in young adults.
  • While aortic surgery improves prognosis, long-term reoperation rates remain high.
  • Factors influencing long-term outcomes in surgically treated Chinese MFS patients are not well understood.

Purpose of the Study:

  • To investigate factors influencing long-term prognosis, including reoperation and mortality rates, in Chinese patients with Marfan syndrome after aortic surgery.

Main Methods:

  • Retrospective clinical investigation at an academic medical center.
  • Included 125 Marfan syndrome patients who underwent aortic surgery.
  • Data analyzed for in-hospital/30-day mortality, survival rates, and reoperation rates.

Main Results:

  • The most common procedure was the Bentall (92 patients). In-hospital/30-day mortality was 1.6%.
  • Survival rates were 97.5% (1 year), 91.4% (5 years), and 74.2% (10 years).
  • Reoperation rates were 2.5% (1 year), 12.9% (5 years), and 32.9% (10 years). Increased systolic blood pressure predicted death; body mass index and smoking predicted reoperation.

Conclusions:

  • Identified key factors influencing prognosis in Chinese MFS patients post-aortic surgery.
  • Managing elevated systolic blood pressure, body mass index, and smoking may improve outcomes.
  • These findings aid healthcare professionals in optimizing MFS patient care after aortic procedures.

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