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Self-organized models of selectivity in calcium channels

Janhavi Giri1, James E Fonseca, Dezsö Boda

  • 1Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA.

Physical Biology
|January 26, 2011
PubMed
Summary

Calcium channel selectivity relies on charge density in the filter, not side chain flexibility. Mobile side chains ensure proper ion passage, with flexibility being a secondary factor in calcium versus sodium selectivity.

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