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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Single-dose therapy of infectious diseases
Canadian Family Physician Medecin De Famille Canadien
|January 26, 2011
Summary
Single-dose antimicrobial therapy offers advantages for infections like trichomonas vaginitis and uncomplicated cystitis. Co-trimoxazole demonstrates effectiveness and safety for single-dose bacterial cystitis treatment in women.
Area of Science:
- Pharmacology
- Infectious Diseases
- Urology
Background:
- Single-dose antimicrobial therapy presents advantages over multi-dose regimens.
- Historically, long-acting penicillins were used for single-dose treatments of streptococcal pharyngitis and syphilis.
- Shorter-acting agents are increasingly utilized for non-invasive mucosal infections.
Purpose of the Study:
- To evaluate the efficacy and safety of single-dose antimicrobial therapy for various infections.
- To address the controversy surrounding single-dose therapy for bacterial cystitis.
- To highlight effective single-dose treatment options for uncomplicated cystitis.
Main Methods:
- Review of existing literature on single-dose antimicrobial therapies.
- Analysis of efficacy data for metronidazole in trichomonas vaginitis.
- Assessment of evidence for co-trimoxazole in uncomplicated bacterial cystitis.
Main Results:
- A single 2g dose of metronidazole is approximately 92% effective for trichomonas vaginitis, considered a treatment of choice.
- Evidence supports the effectiveness and safety of 2 or 3 double-strength tablets of co-trimoxazole for uncomplicated bacterial cystitis in healthy women.
Conclusions:
- Single-dose therapy is a viable and advantageous treatment strategy for specific infections.
- Co-trimoxazole is a highly effective and safe single-dose option for uncomplicated bacterial cystitis.
- Further research may clarify the role of single-dose therapy in other conditions.
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