Assessment of qualitative changes of Acid mucins among sudanese colorectal carcinoma patients
Yosef Mohamed-Azzam Zakout1, Yousra Altegani Ezeldeen
1Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, P.O. Box 11081, Khartoum, 11111, Sudan. yosifzakot@yahoo.com
Purpose:
This study aimed to assess the qualitative changes in the amount of acid mucin in colorectal carcinoma (CRC) compared to normal colon.
Methods:
A total number of 100 samples were examined, 50 were colorectal cancer samples (cases) and 50 were normal (controls), all were stained with Alcian blue method.
Results:
Acid mucin increased, in different levels, in 30 (60%) of the cases compared to only six (12%) of controls (P < 0.0001). However, complete absence of acid mucin was detected among 10 (20%) of cases compared to none among controls.
Conclusions:
CRC is associated with secretion of increased amounts of acid mucin in most cases, and that should be considered as a valuable histological finding.
