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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: Jun 5, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

Aberrant microRNA expression in human cervical carcinomas.

Qunxian Rao1, Qingli Shen, Hui Zhou

  • 1Department of Gynecologic Oncology, The Second Affiliated Hospital of SunYat-sen University, 510120 Guangzhou, People's Republic of China.

Medical Oncology (Northwood, London, England)
|January 26, 2011
PubMed
Summary

Altered microRNA (miRNA) expression is present in cervical cancer tissues compared to normal tissues. These findings suggest a potential role for miRNA dysregulation in cervical cancer development, warranting further investigation.

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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Last Updated: Jun 5, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Altered microRNA (miRNA) expression is a hallmark of various diseases.
  • Human papillomavirus (HPV) infection is a primary cause of cervical cancer.

Purpose of the Study:

  • To compare miRNA expression profiles in human cervical cancer tissues versus adjacent normal tissues.
  • To investigate the relationship between miRNA expression and clinicopathological features in cervical cancer.

Main Methods:

  • Microarray analysis of 924 miRNA probes.
  • Comparison of miRNA expression in cervical cancer and normal cervical tissues from 13 HPV-infected patients.
  • Correlation analysis with lymph node status, vascular invasion, and differentiation.

Main Results:

  • 18 miRNAs were significantly upregulated (≥2×) and 19 miRNAs were significantly downregulated (≤0.5×) in cervical cancer tissues.
  • No significant association was found between miRNA expression and lymph node involvement, vascular invasion, or pathological differentiation.

Conclusions:

  • Cervical cancer tissues exhibit distinct miRNA expression patterns compared to normal tissues.
  • Aberrant miRNA expression may contribute to cervical cancer pathogenesis.
  • Further research is needed to elucidate the role of specific miRNAs in cervical cancer development.