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Body weight-tailored contrast material injection protocol for 64-detector row computed tomography coronary

Tsuyoshi Isogai1, Masahiro Jinzaki, Yutaka Tanami

  • 1Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan.

Japanese Journal of Radiology
|January 26, 2011
PubMed

Insights

Optimal coronary CT attenuation requires at least 0.7 ml/kg of contrast material with 350 mg/ml iodine concentration for 64-detector CT angiography. This protocol ensures higher attenuation values for better diagnostic accuracy.

Area of Science:

  • Radiology
  • Medical Imaging
  • Cardiovascular Imaging

Background:

  • Coronary CT angiography (CCTA) is crucial for diagnosing coronary artery disease.
  • Optimal contrast material attenuation is essential for accurate CCTA interpretation.
  • Body weight-tailored contrast injection protocols aim to standardize image quality.

Purpose of the Study:

  • To evaluate a body weight-tailored contrast material injection protocol for 64-detector computed tomography (CT) coronary angiography.
  • To determine the optimal contrast material volume and iodine concentration for achieving superior coronary CT attenuation.

Main Methods:

  • Sixty patients undergoing CCTA were divided into three groups receiving different contrast protocols (A, B, C) varying in volume (0.6-0.7 ml/kg) and iodine concentration (300-350 mg/ml).
  • Contrast injection duration was standardized at 10 seconds for all participants.
  • Intracoronary attenuation values were analyzed on a per-vessel and per-patient basis, comparing proportions exceeding 325 HU.

Main Results:

  • Protocol C (0.7 ml/kg, 350 mg/ml iodine) significantly increased the likelihood of exceeding 325 HU compared to protocols A and B.
  • On per-vessel analysis, protocol C achieved >325 HU in 95% (reader 1) and 90% (reader 2) of cases.
  • Per-patient analysis also showed significantly higher rates of >325 HU with protocol C.

Conclusions:

  • A minimum of 0.7 ml/kg contrast material with 350 mg/ml iodine concentration is necessary for optimal coronary CT attenuation (>325 HU) using 64-detector CT.
  • This finding is critical for enhancing diagnostic accuracy in CCTA.
  • The study supports the use of higher iodine concentrations and specific volumes for improved CCTA quality.
Abstract

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