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[Effect of prolonged infusion of propofol on the liver mitochondria respiratory function in rabbits]
Xian-xiang Tong1, Yi Kang, Feng-zhi Liu
1Laboratory of Anesthesia and Cirtical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the changes of respiratory function of liver mitochondria in rabbits induced by the general anesthetic propofol.
Methods:
Eighteen New Zealand rabbits weighted 1.5-2.5 kg were randomly divided into three groups: control group, emulsion group and propofol group. The control group received continuous infusion of 0.9% sodium chloride solution. The propofol group received continuous infusion of 1% propofol. The emulsion group received continuous infusion of 10% emulsion. The liver mitochondri of the rabbits were isolated. The carnitine acyl transferase (CPT) activity, H+ -ATPase hydrolysis activity and the content of ATP in the mitochondria were analysed.
Results:
The rabbits in the propofol group had lower activity of CPT than the controls (P < 0.05), while no difference was found between the control group and the emulsion group (P > 0.05). The rabbits in the propofol group had higher H+ -ATPase hydrolysis activity than the controls (P < 0.05), while no difference was found between the control group and the emulsion group (P > 0.05). No significant differences were found in the content of ATP in mitochondria between the three groups (P > 0.05).
Conclusion:
Propofol inhibits CPT activity, which disturbs fatty acid beta-oxidation. Emulsion acted as vehicle of propofol seems to have no significant impact on mitochondria respiratory function.
