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Silk coating on poly(ε-caprolactone) microspheres for the delayed release of vancomycin

Jian Zhou1, TaoLin Fang, Jianchuan Wen

  • 1Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Journal of Microencapsulation
|January 27, 2011
PubMed

Insights

Silk fibroin coating effectively reduces initial vancomycin burst release from poly(ε-caprolactone) microspheres. This silk coating prolongs drug delivery, potentially improving osteomyelitis treatment outcomes.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Orthopaedic Surgery

Background:

  • Osteomyelitis treatment is challenging, with controlled vancomycin release from microspheres showing promise.
  • Large initial burst release from vancomycin-loaded poly(ε-caprolactone) (PCL) microspheres can hinder sustained therapeutic levels.
  • Maintaining drug concentration above the minimum inhibitory concentration for extended periods is crucial for effective infection elimination.

Purpose of the Study:

  • To explore silk fibroin (SF) as an aqueous coating for vancomycin-loaded PCL microspheres.
  • To investigate the impact of SF coating on in vitro vancomycin release kinetics.
  • To assess the potential of SF coating for improving drug delivery in osteomyelitis treatment.

Main Methods:

  • Preparation and characterization of vancomycin-loaded PCL microspheres with and without SF coating.
  • Analysis of particle size, vancomycin content, and material properties using FTIR and DSC.
  • Scanning electron microscopy (SEM) for surface morphology evaluation.
  • In vitro drug release studies to assess release profiles over time.

Main Results:

  • Silk fibroin coating successfully reduced the initial burst release of vancomycin.
  • SF coating significantly retarded the overall vancomycin release rate from PCL microspheres.
  • Characterization confirmed the integrity and composition of the coated microspheres.

Conclusions:

  • Silk fibroin serves as an effective aqueous coating material for vancomycin-loaded PCL microspheres.
  • SF coating offers a viable strategy to prolong vancomycin release, addressing limitations of burst release.
  • This approach holds potential for enhancing anti-infection effects in osteomyelitis management through sustained drug delivery.

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