Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of lymphokine (interleukin-2)-activated killer activity in peripheral blood after administration of natural

H Yanagawa1, S Sone, A Okubo

  • 1Third Department of Internal Medicine, University of Tokushima School of Medicine.

Japanese Journal of Clinical Oncology
|December 1, 1990
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation.

Die Pharmazie·2018
Same author

Occurrence of Bound Salt in Freeze-concentrated Soy Sauce.

Bioscience, biotechnology, and biochemistry·2016
Same author

Calibrating estimates of phage-induced mortality in marine bacteria: Ultrastructural studies of marine bacteriophage development from one-step growth experiments.

Microbial ecology·2013
Same author

A polarized neutron study of the magnetization distribution in Co₂FeSi.

Journal of physics. Condensed matter : an Institute of Physics journal·2013
Same author

Abstracts from Japanese journal of hygiene(nihon eiseigaku zasshi) Vol.54 No.2.

Environmental health and preventive medicine·2011
Same author

Abstracts from japanese journal of hygiene (Nihon Eiseigaku Zasshi) Vol.54 No.3.

Environmental health and preventive medicine·2011

Natural human interferon-gamma (IFN-gamma) injections reduced Leu-11a positive cells and lymphokine-activated killer (LAK) activity in healthy volunteers. Natural killer (NK) activity and monokine production remained unchanged, suggesting IFN-gamma impacts LAK precursor recruitment.

Area of Science:

  • Immunology
  • Cell Biology
  • Pharmacology

Background:

  • Interferon-gamma (IFN-gamma) is a cytokine with broad immunomodulatory and anti-tumor effects.
  • Its in vivo effects on specific immune cell populations and activities require further elucidation.

Purpose of the Study:

  • To analyze the immunologic parameters of blood mononuclear cells after natural human IFN-gamma administration in a phase I study.
  • To investigate the impact of IFN-gamma on Leu-11a positive cells, natural killer (NK) activity, lymphokine (interleukin-2)-activated killer (LAK) activity, and monokine production.

Main Methods:

  • Healthy volunteers received intramuscular injections of natural human IFN-gamma.
  • Blood mononuclear cells, lymphocytes, and monocytes were analyzed before and 24 hours after injection.

Related Experiment Videos

  • Measurements included the percentage of Leu-11a positive cells, NK activity, LAK activity, and monokine production.

    • Main Results:

    • A significant reduction in the percentage of Leu-11a positive cells and LAK activity was observed post-IFN-gamma injection.
    • Natural killer (NK) activity and monokine production levels remained unchanged.
    • These changes suggest IFN-gamma's direct or indirect influence on Leu-11a positive cells.

    Conclusions:

    • In vivo IFN-gamma administration modulates specific immune cell populations and activities.
    • IFN-gamma appears to reduce LAK activity by altering the recruitment of LAK precursors in the blood.
    • Further research is warranted to understand the precise mechanisms of IFN-gamma's immunomodulatory effects.