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Related Experiment Video

Updated: Jun 5, 2026

Controlled Odor Mimic Permeation Systems for Olfactory Training and Field Testing

Controlled Odor Mimic Permeation Systems for Olfactory Training and Field Testing

Published on: January 28, 2021

Rose odor can innately counteract predator odor.

Mutsumi Matsukawa¹, Masato Imada, Toyotaka Murakami

¹Department of Functional Morphology, Nihon University School of Medicine, Itabashi, Tokyo 173-8610, Japan. matsukawa.mutsumi@nihon-u.ac.jp

|January 27, 2011

Summary

Rose odor can counteract predator odor-induced stress responses in mice, even with novel substances. This suggests innate odor counteraction mechanisms exist, impacting neural circuits like the mBST and APC.

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Area of Science:

Neuroscience
Olfactory system research
Stress response mechanisms

Background:

Predator odor exposure activates the hypothalamo-pituitary-adrenal (HPA) axis, inducing stress behaviors.
The medial bed nucleus of the stria terminalis (mBST) is implicated in predator odor processing, but mechanisms are unclear.
The existence of innate odorants that counteract predator odors, even novel ones, is unknown.

Purpose of the Study:

To investigate if rose odor can counteract the stress response induced by predator odor (TMT) in mice.
To identify brain regions involved in this counteraction.
To explore innate odor-based stress mitigation strategies.

Main Methods:

Mice were exposed to rose odor with or without 2,5-Dihydro-2,4,5-trimethylthiazoline (TMT).
Neuronal activation was quantified by counting cells in specific brain regions: mBST, anterior piriform cortex (APC), and olfactory bulb (OB).
Comparisons were made between TMT-only and TMT-plus-rose odor exposure groups.

Main Results:

A mixture of TMT and rose odor significantly reduced activated cells in the mBST and ventrorostral APC compared to TMT alone.
No significant differences in neuronal activation were observed in the dorsal APC or OB between the groups.
Rose odor mitigated TMT-induced neural activation in specific brain areas.

Conclusions:

Rose odor may counteract TMT-induced stress responses, potentially by suppressing neural circuits leading to the mBST.
The findings suggest the existence of innate odorants capable of counteracting predator odor stress, even without prior experience.
This highlights a potential mechanism for innate odor-based stress modulation in the olfactory system.