Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

The Small x Assumption

The Small x Assumption

If a reaction has a small equilibrium constant, the equilibrium position favors the reactants. In such reactions, a negligible change in concentration may occur if the initial concentrations of reactants are high and the Kc value is small. In such circumstances, the equilibrium concentration is approximately equal to its initial concentration. This estimation can be used to simplify the equilibrium calculations by assuming that some equilibrium concentrations are equal to the initial...

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

Scanning Electron Microscopy

Scanning Electron Microscopy

A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
Fundamental Principles
Accelerated...

Overview of Microscopy Techniques

Overview of Microscopy Techniques

The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Migraine associated with road traffic accidents in United Arab Emirates.

Neurosciences (Riyadh, Saudi Arabia)·2013

Same author

Ghosts: their appearance during bereavement.

Canadian family physician Medecin de famille canadien·2011

Same author

Computers and medical decision making.

Canadian family physician Medecin de famille canadien·2011

Same author

Assessing the quality of care in family physicians' practices.

Canadian family physician Medecin de famille canadien·2011

Same author

Referrals and investigation patterns in a family physician group: questions for teaching cost containment.

Canadian family physician Medecin de famille canadien·2011

Same author

Satisfaction and wait time of patients visiting a family practice clinic.

Canadian family physician Medecin de famille canadien·2011

Search research articles

Related Experiment Video

Updated: May 17, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

The microcomputer as a tool for literature searches.

Canadian Family Physician Medecin De Famille Canadien

|January 27, 2011

Summary

Physicians can now perform computer literature searches using readily available technology. This guide covers essential hardware, software, and databases for effective medical information retrieval.

Area of Science:

Medical Informatics
Information Science

Background:

Physician access to computerized databases has expanded significantly over recent decades.
Microcomputer technology enables physicians to conduct their own literature searches.

Purpose of the Study:

To describe the available hardware, software, and databases for computer-assisted literature searches.
To illustrate the technique of computer literature searching with practical examples.

Main Methods:

Overview of essential hardware and software components for computer searches.
Description of prominent database providers like Dialog and Bibliographic Retrieval Services.
Inclusion of illustrative examples of performing literature searches.

Main Results:

More Related Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

Related Experiment Videos

Last Updated: May 17, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

Physicians can independently access and search medical literature using microcomputers.
Key database providers and search techniques are detailed.
Essential skills for conducting searches are outlined.

Conclusions:

Physicians can benefit from performing their own computer literature searches.
Understanding available resources and basic search skills is crucial.
The article highlights both the advantages and disadvantages for physicians conducting self-directed searches.