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Serum C-reactive protein level and prediabetes in two Asian populations

C Sabanayagam1, A Shankar, S C Lim

  • 1Department of Community Medicine, West Virginia University School of Medicine, PO Box 9190, Morgantown, WV 26506-9190, USA. csabanayagam@hsc.wvu.edu

Diabetologia
|January 27, 2011
PubMed

Insights

Elevated high-sensitivity C-reactive protein (hsCRP) levels are linked to prediabetes in Asian adults. This inflammation marker may indicate increased risk for developing diabetes and cardiovascular disease.

Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Health
  • Inflammation Biomarkers

Background:

  • Prediabetes signifies an intermediate stage of hyperglycemia, escalating the risk of diabetes and cardiovascular disease (CVD).
  • C-reactive protein (CRP) is a recognized inflammation marker associated with diabetes and CVD.
  • Limited research exists on the CRP-prediabetes association in non-diabetic populations.

Purpose of the Study:

  • To investigate the association between serum high-sensitivity C-reactive protein (hsCRP) levels and prediabetes.
  • To analyze this association in two large, population-based Asian cohorts free of diabetes.

Main Methods:

  • Data from the Singapore Prospective Study Programme (SP2) and Singapore Malay Eye Study (SiMES) were analyzed.
  • Participants (n=6,589) were free of diabetes mellitus.
  • Prediabetes was defined using glycated hemoglobin (HbA1c) or fasting plasma glucose (FPG) criteria.

Main Results:

  • Elevated hsCRP levels showed a significant association with prediabetes after adjusting for multiple confounders.
  • In SP2, odds ratios (ORs) for prediabetes increased with hsCRP levels (1-3 mg/l: 1.31; >3 mg/l: 2.17).
  • In SiMES, hsCRP >3 mg/l was associated with higher prediabetes odds (OR: 1.31), with stronger associations observed in women, Chinese, Malays, and leaner individuals (BMI < 25 kg/m²).

Conclusions:

  • Findings from two Asian cohorts suggest elevated serum hsCRP levels are associated with prediabetes.
  • hsCRP may serve as a potential biomarker for identifying individuals at risk of prediabetes.
  • Further research could explore the clinical implications of hsCRP in prediabetes management.
Abstract

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