Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RETRACTED: Kim et al. The p53-Driven Anticancer Effect of <i>Ribes fasciculatum</i> Extract on AGS Gastric Cancer Cells. <i>Life</i> 2022, <i>12</i>, 303.

Life (Basel, Switzerland)·2026
Same author

Diagnosing HCC with conventional and late portal venous phase MRI: intraindividual comparison of MRI with extracellular contrast agent.

European radiology·2025
Same author

Reply.

Gastroenterology·2025
Same author

Effectiveness of noncontrast-abbreviated magnetic resonance imaging in a real-world hepatocellular carcinoma surveillance.

European radiology·2025
Same author

Noncontrast Magnetic Resonance Imaging vs Ultrasonography for Hepatocellular Carcinoma Surveillance: A Randomized, Single-Center Trial.

Gastroenterology·2025
Same author

The Beneficial Roles of Seaweed in Atopic Dermatitis.

Marine drugs·2024
Same journal

Abstracts of selected papers from the current literature.

Abdominal imaging·2016
Same journal

How the radiologist can add value in the evaluation of the pre- and post-surgical pancreas.

Abdominal imaging·2015
Same journal

Erratum to: Hot spleen: hypervascular lesions of the spleen.

Abdominal imaging·2015
Same journal

Cross-sectional imaging, with surgical correlation, of patients presenting with complications after remote bariatric surgery without bowel obstruction.

Abdominal imaging·2015
Same journal

The ability of 18F-choline PET/CT to identify local recurrence of prostate cancer.

Abdominal imaging·2015
Same journal

T1-hyperintense renal lesions: can high signal predict lack of enhancement?

Abdominal imaging·2015
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma
07:47

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Published on: August 31, 2022

Hepatocarcinogenesis: imaging-pathologic correlation.

Young Nyun Park1, Myeong-Jin Kim

  • 1Department of Pathology, Brain Korea 21 Project and Institute of Gastroenterology, Center for Chronic Metabolic Disease, Yonsei University Health System, Seoul, Republic of Korea.

Abdominal Imaging
|January 27, 2011
PubMed
Summary
This summary is machine-generated.

Accurate diagnosis of early hepatocellular carcinoma (HCC) requires understanding premalignant liver lesions. This review details pathological and radiological features of dysplastic nodules (DNs) and their progression to HCC.

More Related Videos

A Hepatocellular Cancer Patient&#45;Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth
08:15

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

Published on: February 2, 2024

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Related Experiment Videos

Last Updated: Jun 5, 2026

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma
07:47

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Published on: August 31, 2022

A Hepatocellular Cancer Patient&#45;Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth
08:15

A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth

Published on: February 2, 2024

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Area of Science:

  • Hepatology
  • Oncology
  • Radiology

Background:

  • Advances in liver surgery and imaging necessitate clear nomenclature for precancerous liver lesions.
  • Hepatocellular carcinoma (HCC) development involves premalignant stages like dysplastic foci and nodules (DNs).
  • Accurate characterization of borderline nodules remains a diagnostic challenge in hepatocarcinogenesis.

Purpose of the Study:

  • To provide clinically relevant nomenclature for premalignant and early hepatocellular carcinoma (HCC) lesions.
  • To discuss the pathological and radiological features of small nodular lesions in the liver.
  • To elucidate the multistep process of hepatocarcinogenesis from dysplastic nodules (DNs) to HCC.

Main Methods:

  • Review of pathological features of dysplastic foci and nodules (DNs).
  • Analysis of radiological characteristics of small arterially enhancing or hypovascular liver nodules.
  • Correlation of imaging findings with histopathological progression to HCC.

Main Results:

  • Dysplastic nodules (DNs) exhibit cytologic and structural atypia, representing precancerous lesions.
  • Small arterially enhancing or hypovascular nodules present diagnostic challenges in imaging.
  • Understanding the progression from DNs to HCC is crucial for early diagnosis.

Conclusions:

  • Standardized nomenclature for premalignant liver lesions is essential for clinical practice.
  • Integrated pathological and radiological assessment aids in characterizing borderline nodules.
  • Insights into hepatocarcinogenesis progression improve early detection of HCC.