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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Cancer02:18

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Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
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True local recurrences do not metastasize.

Dieter Hölzel1, Rebecca T Emeny, Jutta Engel

  • 1Munich Cancer Registry (MCR), Munich Cancer Center (MCC), Institute of medical Informatics, Biometry and Epidemiology (IBE), Ludwig-Maximilians-University (LMU) Munich, Munich, Germany. hoe@ibe.med.uni-muenchen.de

Cancer Metastasis Reviews
|January 27, 2011
PubMed
Summary
This summary is machine-generated.

Field cancerization impacts local tumor control, particularly in breast cancer (BC) recurrence after breast-conserving surgery. Understanding true recurrences, new primaries, and residual tumors aids in managing ipsilateral breast tumor recurrences (IBTR).

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Local tumor control is often limited by the concept of "field cancerization", observed in various cancers including oral, lung, prostate, and breast cancer.
  • Ipsilateral breast tumor recurrences (IBTR) after breast-conserving surgery (BCS) represent a significant clinical challenge in breast cancer (BC) management.

Purpose of the Study:

  • To review the problem of ipsilateral breast tumor recurrences (IBTR) in breast cancer (BC) following breast-conserving surgery.
  • To distinguish between true recurrences, new primary tumors, and residual tumors as causes of local recurrence.
  • To discuss the time-dependent risk and underlying hypotheses for these recurrence types, exploring their generalizability to other cancers.

Main Methods:

  • Review of existing data on breast cancer (BC) to describe the time-dependent risk of different types of local recurrences (true recurrences, new primaries, residual tumors).
  • Estimation of the time of initiation and growth duration for ipsilateral breast tumor recurrences (IBTR) relative to the primary tumor diagnosis.
  • Analysis of two hypotheses explaining the observed data on local recurrences and their potential metastasis.

Main Results:

  • Breast cancer (BC) data allow for the description of time-dependent risks for true recurrences, new primaries, and residual tumors.
  • The time of initiation and growth duration of ipsilateral breast tumor recurrences (IBTR) can be estimated relative to the primary tumor (PT).
  • Two hypotheses suggest local recurrences may initiate years before primary diagnosis or that true local recurrences have limited metastatic potential.

Conclusions:

  • The concept of "field cancerization" is relevant to understanding local tumor control limits, particularly for ipsilateral breast tumor recurrences (IBTR) in breast cancer (BC).
  • Distinguishing between recurrence types and understanding their initiation times are crucial for managing breast cancer (BC) and potentially other malignancies.
  • The hypotheses presented offer insights into the biology of local tumor recurrence and may have implications for treatment strategies and prognosis.