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Updated: Jun 5, 2026
A Modified Co-Culture System for Understanding Granulosa-Theca Cell Interactions in the Bovine Ovary
Published on: September 19, 2025
[Granulosa cell tumors: a study of 7 cases]
Dorra Zeghal Souki1, Haifa Bouchahda, Mehdi Kehila
1Universite Tunis, El Manar, Tunisie.
Background:
The granulosa tumors have been described for the first time in 1855 by Rokitansky.
Aims:
To investigate the epidemiological and pathological characteristics of granulosa tumors, and the prognostic factors to determine therapy management.
Methods:
Our study is retrospective about 7 cases of granulosa cells tumors treated and monitored at the department C of Gynecology and Obstetrics in the Center of Maternity and Neonatology of Tunis.
Results:
The average age of our patients was 40 years. The circumstances of discovery are dominated by pelvic pain (3 cases); menometrorrhagia and post-menopausal bleeding (2 cases) and secondary amenorrhea (2 cases). The sonographic most frequent aspect was solido-cystic (3 cases). The final pathologic examination revealed 6 cases of granulosa adult type tumor and one juvenile type. Five tumors were classified as stage Ia, one tumor was stage Ic and one stage IIa. The treatment was conservative in most cases. An ilioobturator and para-aortic lymphadenectomy was performed in 3 cases. Two patients had adjuvant chemotherapy. Six patients were in complete remission at the last inspection. There were two cases of pregnancies carried till birth after surgical treatment.
Conclusion:
The granulosa tumors are characterized by their natural history with a slow and indolent character and their secretion of sex hormones.
