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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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[Task-orientated therapy (target-therapy) directed to patients with renal cell carcinoma]

A F Vozianov, A K Butenko, K P Zak

    Likars'Ka Sprava
    |January 27, 2011
    PubMed

    Insights

    Targeted therapies, including tyrosine kinase inhibitors and mTOR inhibitors, offer new treatment options for metastatic renal cell carcinoma (mRCC). This review analyzes their effectiveness, patient tolerance, and side effects in mRCC therapy.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Pharmacology

    Background:

    • Metastatic renal cell carcinoma (mRCC) pathogenesis involves VHL gene mutations and the mTOR pathway.
    • These pathways stimulate tumor development, proliferation, and angiogenesis.

    Purpose of the Study:

    • To review the antitumor activity of novel targeted therapies for mRCC.
    • To analyze patient tolerance and side effects of these treatments.

    Main Methods:

    • Literature review of tyrosine kinase inhibitors (e.g., sunitinib, sorafenib) and mTOR inhibitors (e.g., everolimus, temsirolimus).
    • Analysis of clinical data on efficacy, safety, and patient tolerance.

    Main Results:

    • Tyrosine kinase inhibitors and mTOR inhibitors represent a new generation of mRCC treatments.
    • Bevacizumab, a monoclonal antibody, is also discussed for its anti-VEGF activity.

    Conclusions:

    • Targeted therapies have shown significant promise in mRCC treatment.
    • Further analysis of efficacy, tolerance, and side effect profiles is crucial for optimizing patient care.

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