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Updated: Jun 4, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[Serological and clinical aspects in initial Wegener's disease. A case report]
Caterina Defendenti1, Giacinto Guercilena, Angela Freschi
1Laboratorio Analisi, Servizio di Sierologia e Autoimmunità, Ospedale Fatebenefratelli, Milano. caterina.defendenti@fbf.milano.it
Abstract:
The clinical and biochemical features of an acute and initial Wegener's granulomatosis case were analysed in a young woman. A multifactorial aspects are evident. A chronic inflammation of the superior respiratory tract has been observed. Staphylococcus aureus has been isolated. An oligoclonal component constituted of high levels of anti-PR3 autoantibodies was detected: initial autoreactive B cell clone activation is probable. The chronological link with postpartum is present: our study excluded foetal microchimerism; the hormonal state can be a trigger factor. Serical IL-17 was negative.
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