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Updated: Jun 4, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
A scoping review of the use of theory in studies of knowledge translation
Heather L Colquhoun1, Lori J Letts, Mary C Law
1School of Rehabilitation Sciences, McMaster University, IAHS Bldg., 1400 Main St. W., Hamilton, ON, L8S 1C7. colquhhl@mcmaster.ca
Background:
Advancing the science of knowledge translation (KT) in occupational therapy is critical. Explicit application of theory can advance this science; yet, how theory is applied and the degree to which it can guide research remain poorly defined.
Purpose:
To understand how theory is applied within KT research.
Methods:
A scoping review was conducted to examine and summarize the extent, range, and nature of the application of three specific KT theories: Diffusion of Innovations, Promoting Action on Research Implementation in Health Services framework, and Theory of Planned Behaviour.
Findings:
Theory use was seen most frequently in medicine and nursing. Only 3 of 90 articles were in rehabilitation. Five approaches to theory application were found, the most common being the use of to predict success of KT (57/90).
Implications:
In-depth study of the importance and methods of theory application in KT research is needed, in particular in occupational therapy.
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